Malonate Series

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Diethyl malonate, also known as DEM, is the diethyl ester of malonic acid. It occurs naturally in grapes and strawberries as a colourless liquid with an apple-like odour, and is used in perfumes. It is also used to synthesize other compounds such as barbiturates, artificial flavourings, vitamin B1, and vitamin B6.

Dimethyl malonate is a diester derivative of malonic acid. It is a common reagent for organic synthesis used, for example, as a precursor for barbituric acid. It is also used in the malonic ester synthesis. It can be synthesized from dimethoxymethane and carbon monoxide.

Dimethyl malonate is used extensively in the fragrance industry as a raw material in the synthesis of jasmonates. For example, methyl dihydrojasmonate is synthesized from cyclopentanone, pentanal and dimethyl malonate. Hedione is used in almost all fine fragrances and is found in Christian Dior's Eau Sauvage and "Diorella", Hermes' "Voyage d'Hermes Parfum", Calvin Klein's "CKOne", Chanel's "Chanel No. 19", and Mark Jacob's "Blush", among others. 

The pure product of diisopropyl malonate is a colorless transparent liquid, with a slight ester fragrance, and the industrial product is slightly yellow, bp99～100℃/177.8Pa, n20D1.4120, relative density 0.991, insoluble in water, Soluble in organic solvents such as esters, benzene and ether.

Uses: Used as an intermediate for medicines and pesticides; it is an intermediate for the fungicide Pyricularia.

An important organic material containing many active groups in a

molecule can be condensed and annulled with a variety of substances,and is now mainly used to synthesize fluperic acid.

Organic synthetic raw materials 

used in medicine, dyestuff and other

products.